中国医科大学2021年12月《药物代谢动力学》作业考核试题...
中国医科大学2021年12月《药物代谢动力学》作业考核试题1.[单选题] 下列情况可称为首关效应的是:()<img id="PIqautpitem20211105052019869.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIqautpitem20211105052019869.png?Expires=1951464019&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=kHtHL6KEBEMgHdc5AdnP8zecBHk%3D" />
A.A
B.B
C.C
D.D
E.E
答:——D——
2.[单选题] 易通过血脑屏障的药物是:()<img id="PIegjimitem20211105052019980.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIegjimitem20211105052019980.png?Expires=1951464020&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=yo0k%2BC9hyvThP94zWp2ktvJGHXY%3D" />
A.A
B.B
C.C
D.D
E.E
答:——B——
3.[单选题] 药物转运最常见的形式是:()<img id="PIgpttritem20211105052020121.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIgpttritem20211105052020121.png?Expires=1951464020&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=cGAauG33LxZRrZu5XgQEpgWj3Cs%3D" />
A.A
B.B
C.C
D.D
E.E
答:——B——
4.[单选题] <img id="PIuwdxkitem20211105052020288.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIuwdxkitem20211105052020288.png?Expires=1951464020&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=y3x6W8nwOJ1EsftMNVj1U1etC8A%3D" /><img id="PIatsanitem20211105052020470.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIatsanitem20211105052020470.png?Expires=1951464020&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=i5AFauOd9iUJ%2BNC86w%2B%2BJcCg%2BCQ%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
5.[单选题] <img id="PIorjsxitem20211105052020525.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIorjsxitem20211105052020525.png?Expires=1951464020&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=hvQBu1yukGChvr9ec5Jfj5BYAZE%3D" /><img id="PIoxmbvitem20211105052020681.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIoxmbvitem20211105052020681.png?Expires=1951464020&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=vBKWtYWB3w%2BrzC%2FgewmymCSSFAg%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
6.[单选题] <img id="PIzvggvitem20211105052020861.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIzvggvitem20211105052020861.png?Expires=1951464020&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=iyrOCJk%2BZuWlGQDZ0L6Oi1%2FyqNo%3D" /><img id="PIiecqiitem20211105052020976.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIiecqiitem20211105052020976.png?Expires=1951464021&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=YDjxLdxTmzoXyFgtbfJ5bb9zCS0%3D" /><img id="PInbwfiitem20211105052021111.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PInbwfiitem20211105052021111.png?Expires=1951464021&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=QFOKZUU%2BNOIjWHYgPIbQqcxr65c%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
7.[单选题] <img id="PIckzymitem20211105052021277.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIckzymitem20211105052021277.png?Expires=1951464021&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=o%2BSnyrjcOw1J19lC4zUJly1Mtfs%3D" /><img id="PIolgvxitem20211105052021455.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIolgvxitem20211105052021455.png?Expires=1951464021&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=aiX8ycyriS4%2FjEMi6ZUZ9bGR8FY%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
8.[单选题] <img id="PIktgocitem20211105052021611.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIktgocitem20211105052021611.png?Expires=1951464021&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=Q3PQZbsiWL%2BaH0CIHOUxyRzFXDE%3D" /><img id="PIpjruritem20211105052021709.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIpjruritem20211105052021709.png?Expires=1951464021&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=dJV9hQ0qO0rGyBOjMqQtiQO8Pew%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
9.[单选题] <img id="PIqnjywitem20211105052021821.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIqnjywitem20211105052021821.png?Expires=1951464021&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=DnfAz%2F4nmHlR%2BSKAau5wYu6kI6g%3D" /><img id="PIuiefjitem20211105052021958.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIuiefjitem20211105052021958.png?Expires=1951464022&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=mklL77QI9senlpn5hBSwQN68AT4%3D" /><img id="PIfyvgvitem20211105052022169.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIfyvgvitem20211105052022169.png?Expires=1951464022&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=XroN%2FDxw%2Fqp3HM7OrS%2F1fhqyLq8%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
10.[单选题] <img id="PIdigsditem20211105052022301.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIdigsditem20211105052022301.png?Expires=1951464022&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=CQt1wqJAOPWtdM%2FoHkUDTTUnTtk%3D" /><img id="PIqvzulitem20211105052022411.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIqvzulitem20211105052022411.png?Expires=1951464022&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=R1FABgOmGSNbsuJM6hYi0jG4fUw%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
11.[单选题] <img id="PIcuoklitem20211105052022535.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIcuoklitem20211105052022535.png?Expires=1951464022&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=5ffBnz6ZOLQZIXIvgVDUXMLfwWs%3D" /><img id="PIgeqnlitem20211105052022679.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIgeqnlitem20211105052022679.png?Expires=1951464022&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=JIwAPqi%2Fm1SzEI5XSFPWQfSILPI%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
12.[单选题] <img id="PIedmqeitem20211105052022821.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIedmqeitem20211105052022821.png?Expires=1951464022&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=rKtS868g6%2ByivjJgXNN0xkb6liY%3D" /><img id="PIzoxmsitem20211105052022962.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIzoxmsitem20211105052022962.png?Expires=1951464023&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=4OHNnUgD4lzIVjRZbnDpHO3VJTk%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
13.[单选题] <img id="PInemkxitem20211105052023114.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PInemkxitem20211105052023114.png?Expires=1951464023&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=jBW9LjQElH60eCfNLt07CaQi%2Bvk%3D" /><img id="PIwwfmiitem20211105052023214.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIwwfmiitem20211105052023214.png?Expires=1951464023&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=u2pekoG3Xg4vWArZLfsqoclkXz0%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
14.[单选题] <img id="PIxkcecitem20211105052023439.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIxkcecitem20211105052023439.png?Expires=1951464023&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=pBA4e7A3tQdLHE5JdbaqmOiQbSk%3D" /><img id="PIroackitem20211105052023520.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIroackitem20211105052023520.png?Expires=1951464023&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=n55f%2BKWf1XXf%2Bmd05hBDTeZl4lo%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
15.[单选题] <img id="PIzybxtitem20211105052023725.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIzybxtitem20211105052023725.png?Expires=1951464023&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=7XJdMc%2BoOClL09KPHUSx99Y%2Bmms%3D" /><img id="PIiujliitem20211105052023809.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIiujliitem20211105052023809.png?Expires=1951464023&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=QWEZbKd4rbDlxKEJPshLHBykdkE%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
16.[单选题] <img id="PIzialnitem20211105052023929.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIzialnitem20211105052023929.png?Expires=1951464024&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=4S5YI9n7S1FcH4AEMJr1TsbuTb4%3D" /><img id="PIaojrmitem20211105052024118.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIaojrmitem20211105052024118.png?Expires=1951464024&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=GyNpEGrbVeEwabriTocl6NWzIfY%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
17.[单选题] <img id="PIqqqfaitem20211105052024279.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIqqqfaitem20211105052024279.png?Expires=1951464024&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=SBhjZyb94mzMWu2cCQehhwmoA78%3D" /><img id="PIibzcjitem20211105052024423.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIibzcjitem20211105052024423.png?Expires=1951464024&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=0bCpHGy2IMGlYb6F6Dm2Rjj%2F6%2Bw%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
18.[单选题] <img id="PIswbqpitem20211105052024467.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIswbqpitem20211105052024467.png?Expires=1951464024&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=orhPLu1k9TrPx2MBj1mlepkZ7G4%3D" /><img id="PInikatitem20211105052024607.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PInikatitem20211105052024607.png?Expires=1951464024&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=JTBDAqkM6z3jzClztpbexBeGM%2Bo%3D" /><img id="PIbicgfitem20211105052024724.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIbicgfitem20211105052024724.png?Expires=1951464024&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=i9I02fVWqeo9iZ2dwWA53gNoQ9s%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
19.[单选题] <img id="PIagnocitem20211105052024850.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIagnocitem20211105052024850.png?Expires=1951464024&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=x9gkdOm1pq0iSMwbY5%2FzTqz7Ni4%3D" /><img id="PIlreveitem20211105052024953.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIlreveitem20211105052024953.png?Expires=1951464024&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=DlNYZloB5sOuRaZZWg2j7IKFIiM%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
20.[单选题] <img id="PIycsmaitem20211105052025068.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIycsmaitem20211105052025068.png?Expires=1951464025&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=umu8UyoISM%2FpbDFG7RYicLaO0Hk%3D" /><img id="PImloaditem20211105052025237.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PImloaditem20211105052025237.png?Expires=1951464025&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=MisyiAO0jNAm2ddhLkyIcDgyghQ%3D" />
A.A
B.B
C.C
D.D
E.E
答:————
21.[判断题] <img id="PIfvyynitem20211105052025322.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIfvyynitem20211105052025322.png?Expires=1951464025&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=MSQzwe5nw0nIN5FZqy%2BZcwtlZ14%3D" />
A.对
B.错
答:————
22.[判断题] 一个药物中毒的患者,药物开始从机体消除是一级动力学消除,而体内药量减少到机体能饱和这种药物时,转为零级动力学消除。()
A.对
B.错
答:————
23.[判断题] 若改变每次用药剂量,不改变给药间隔,稳态浓度改变,达到稳态浓度时间和波动幅度不变,波动范围改变。()
A.对
B.错
答:————
24.[判断题] 生物利用度是指药物被机体吸收利用的程度和速度。若吸收量大,峰浓度高,若吸收速度快,峰浓度小,药物出现作用的时间快。()
A.对
B.错
答:————
25.[判断题] <img id="PIilirnitem20211105052025455.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIilirnitem20211105052025455.png?Expires=1951464025&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=Giy%2B1p4NHI7xGUZ%2FTTV8zu5eI14%3D" />
A.对
B.错
答:————
26.[判断题] <img id="PIansxaitem20211105052025584.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIansxaitem20211105052025584.png?Expires=1951464025&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=fYVDIrOhtmWr%2FK0tA86oGaYll6M%3D" />
A.对
B.错
答:————
27.[判断题] <img id="PIfwzqgitem20211105052025736.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIfwzqgitem20211105052025736.png?Expires=1951464025&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=yJmir7FEsFHKiTTxg934k7Af4qo%3D" />
A.对
B.错
答:————
28.[判断题] 静脉注射两种单室模型药物,若给药剂量相同,那么表观分布容积大的药物血药浓度低,而表观分布容积小的药物血药浓度高。()
A.对
B.错
答:————
29.[判断题] <img id="PIujwzritem20211105052025862.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIujwzritem20211105052025862.png?Expires=1951464025&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=yrPClQF9VGoPbudmoZ9ku23nE4k%3D" />
A.对
B.错
答:————
30.[判断题] <img id="PIkphkpitem20211105052026007.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIkphkpitem20211105052026007.png?Expires=1951464026&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=tBMXltXXGUU9mTcEyARS%2BSnkkIY%3D" />
A.对
B.错
答:————
31.[填空题] 药物的体内过程包括##、##、##、##四大过程。
答:————
32.[填空题] 单室模型血管外给药计算ka的两种方法分别为##和##。 答:————
33.[填空题] 消除速率常数k大,表示该药在体内消除##,半衰期##。
答:————
34.[填空题] 双室模型中,将机体分为两个房室,分别称为##、##。
答:————
35.[名词解释] 肝肠循环
答:————
36.[名词解释] <img id="PIogbmvitem20211105052026287.png" src="https://oescdn.open.com.cn/zyglpt/PI/item/2021/1105/PIogbmvitem20211105052026287.png?Expires=1951464026&OSSAccessKeyId=gbI8DRLk7JJhLbEw&Signature=hm0M%2FsvlAXtMSN3a1FoZCQ%2BjI8Y%3D" />
答:————
37.[名词解释] 生物转化
答:————
38.[名词解释] 酶抑制作用
答:————
39.[名词解释] 多室模型
答:————
40.[问答题] 什么是绝对生物利用度和相对生物利用度?两者有何区别?
答:————
41.[问答题] 请说明米氏方程能够代表混合动力学特征的原因。
答:————
42.[问答题] 药物代谢动力学参数计算中为何有时要采用权重的方法?
答:————
43.[问答题] 药物在体内的生物转化分哪两项代谢反应?试述I相代谢反应包括了哪些官能团作用。
答:————
44.[问答题] 何种情况下可考虑进行多次给药后特定组织的药物浓度研究?
答:————
页:
[1]